Focusing on the problem of irrational use of knowledge resources in solving enterprise business problems, a knowledge resource model oriented to business problem solving by using domain-specific modeling method was proposed. First, the basic elements in business problem solving area were described, and the relationship between these objects was analyzed. Second, the process of the business problem solving was formatted by the Problem-Knowledge Event-driven Process Chain (PK-EPC) which built in domain template and associated with corresponding knowledge unit. Third, the business problem was resolved by the application model. And the knowledge unit was associated with the corresponding knowledge carrier. According to previous information, a multi-level problem-solving solution model could be constructed. The solution model included business activities, knowledge units and knowledge carriers, and it provided a fast and accurate method for solving business problems. At last, a business problem solving oriented solution modeling system was designed based on Java, and it demonstrated the feasibility of the knowledge resource model.